SNCA and Parkinson disease: Moreover, a recent study showed that triple knockout (KO) models for the synuclein family show impairment in the endocannabinoid system through a postsynaptic alteration in the SNARE complex, affecting the release of endocannabinoids, which are crucial for neuroplasticity; for instance, the deficiency in endocannabinoids is associated with the onset of PD [118].