SNCA and Parkinson disease: ATP13A2 encodes for ATPase pump, a transmembrane lysosomal protein involved in cation and polyamine transport [69]; knock-out ATP13A2 mice show sensorimotor deficits but with no loss of dopaminergic neurons; moreover, they show features atypical for PD, such as an increase in lipofuscin in the cerebellum and hippocampus and accumulation of insoluble α-synuclein in the hippocampus [70].