IGF1 and osteoarthritis, knee: Synovial fluid analyses one year after an SVF injection showed reduced concentrations of pro-inflammatory molecules (matrix metalloproteinase-2 (MMP-2), IL1-beta, IL-6, and IL-8) and increased concentrations of anti-inflammatory molecules (insulin growth factor-1 (IGF-1) and IL-10) in knee osteoarthritis cases [21].