Various risk factors are responsible for PTL, such as infection (endotoxin), which accounts for 25–40% of cases [8], inflammatory mediators (IL1β, TNF-α) [9], vaginal bleeding (hemorrhage) [10], uterine overdistension [11,12], excessive amniotic fluid volume (polyhydramnios) [13], stress [14], immunological complications, and PROM. This evidence concerns the gene TNF and infection.