CRP and endothelial dysfunction: The predominant physiological markers investigated thus far indicative of the negative impacts of prolonged sitting include observational and experimental studies that have identified acute and chronic effects concerning high plasma glucose [9], endothelial dysfunction [29], high levels of low-density lipoprotein (LDL) and total cholesterol [18,30], suppression of high-density lipoprotein (HDL) [31,32], elevated plasma triglycerides, decreased insulin sensitivity [33], heightened C-reactive protein (CRP) [34,35,36,37], fibrinogen [38,39,40], and white blood cell (WBC) count [39,41].