An ATPase degrader, JQ-dS-4, constructed by linking a BRG1 ATPase inhibitor to a phthalimide, which is a target for cereblon (CRBN) ubiquitin ligase, led to a reduction in chromatin accessibility at BRG1 binding sites and reduced the proliferation of H3K27M-driven gliomas. Here, SMARCA4 is linked to central nervous system cancer.