We reasoned that adding an anti-PDL1 moiety to an anti-BCMA antibody in a bispecific format may thus allow the PD1/PDL1 axis to be blocked within the tumor, since the anti-BCMA moiety would concentrate the antibody mostly in the tumor bed, potentially increasing the efficacy of the anti-BCMA and reducing the systemic toxicity of the anti-PDL1 moiety. This evidence concerns the gene PDCD1 and neoplasm.