Other pro- and anti-inflammatory cytokines, produced by B and T lymphocytes, such as IL-6, IL-10, IL-12 and IL-18, are also involved in SLE pathogenesis, and elevated levels of these cytokines in the serum of SLE patients were found to correlate with the disease activity [59,60,61]. This evidence concerns the gene IL18 and systemic lupus erythematosus.