Importantly, the efficacy of JIB‐04 in enhancing IFN‐β expression and T‐cell infiltration, as well as its antitumour activity were largely diminished in STING‐deficient tumours (Figure S8F,G), highlighting the essential role of STING/type I IFN axis in reshaping the T‐cell‐inflamed TME. The gene discussed is IFNB1; the disease is neoplasm.