Notably, reduced expression levels of EAAT1 and EAAT2 have been observed in cases of epilepsy (127, 128), while mutations in the SLC1A3 and SLC1A2 genes that encodes EAAT1 and EAAT2, can result in episodic ataxia 6, characterized by symptoms of epilepsy, long lasting ataxia attacks and headaches, and epileptic encephalopathies, respectively (129, 130). This evidence concerns the gene SLC1A3 and Epileptic encephalopathy.