APOE and epilepsy: In the context of hyperexcitability, APOE ε4 (APOE4) has not been associated with early-onset epilepsy, within 12 months of age, (76), but APOE4 has been linked to an increased risk of late-onset epilepsy, starting after age 60, and there exists an allele dose dependence on the incidence of late-onset epilepsy of 2.87, 4.13, and 7.05 per 1,000 person-years for 0, 1, and 2 APOE ε4 alleles, respectively (42, 77).