Aldosterone is mainly related to renin angiotensin system, which can cause HBP in patients with IgAN, meanwhile renin angiotensin system blockades are also the recommended IgAN treatment scheme in the guide, which can delay the progress of IgA nephropathy (26), including what we know angiotensin-converting-enzyme-inhibitors and angiotensin-II receptor blockers. This evidence concerns the gene ACE and IgA glomerulonephritis.