Our correlation analysis results show a modest negative correlation between serum sCD40L and sinonasal mucosa CD40L-positive cell level in CRS patients (r = −0.47, p = 0.017, Fig. 1D) and a more significant negative correlation between them in eCRS patients was further observed (r = −0.78, p = 0.011, Fig. 1E). This evidence concerns the gene CD40LG and congenital rubella syndrome.