These studies highlighted immunological dysregulation in genes/pathways associated with the T-cell receptor, CXCL9 [20] and Jak-STAT signaling pathways involving pro-fibrotic genes/proteins, including HBEG, eNAMPT and ANG-2 (angiopoietin-2), which were identified as potential biomarkers of sarcoidosis severity [21–23]. Here, ANGPT2 is linked to sarcoidosis.