No single GWAS SNP achieved significance (p<1x10–8), however, analysis of the eQTL/GWAS SNP pool yielded 621 eQTL SNPs (p<10–4) associated with 730 genes that highlighted innate immunity, MHC Class II, and allograft rejection pathways with multiple SNPs validated in an independent sarcoidosis cohort (105 SNPs analyzed) (NOTCH4, IL27RA, BTNL2, ANXA11, HLA-DRB1). The gene discussed is HLA-DRB1; the disease is sarcoidosis.