The majority of these SNPs were validated in AAs, with rs7549445, the top ranked SNP by p value, related to JAK1 gene, a Janus kinase, key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response, supporting the importance of the JAK-STAT pathway in sarcoidosis [16, 70]. The gene discussed is STAT3; the disease is sarcoidosis.