Candidate gene studies and GWAS studies in European- and African-descent subjects have indicated the HLA region to harbor genetic risk loci, highlighted by SNPs with significant association with sarcoidosis susceptibility within HLA-C, HLA-B, HLA-DRA, HLA-DRB5, HLA-DRB1, HLA-DPB1, HLA-DQA1, and HLA-DQB1 [37, 43, 57, 58]. The gene discussed is HLA-C; the disease is sarcoidosis.