The list of validated SNPs included rs502771 selected after comparison of ADs with sarcoidosis to GAIN controls residing in the HLA chromosome 6p21.3 region harboring HLA-DQA and HLA-DRB5, as well as rs9268362 and rs3094228 identified in EDs and rs502771 and rs7746922 in ADs with sarcoidosis affecting expression of HLA-DRB6 and NOTCH4, a candidate gene in the NOTCH family of T-cell immune response that regulates the activation of Toll-like receptors in macrophages, known to drive chronicity of lung inflammation [62, 63]. This evidence concerns the gene HLA-DRB6 and sarcoidosis.