T2DM patients with CKD showed that SBP [HR (95% CI): 1.018 (1.002–1.035), p = 0.025], Hb [HR (95% CI): 0.979 (0.961–0.997), p = 0.023], ALB [HR (95% CI): 0.952 (0.910–0.996), P = 0.032], glycosylated hemoglobin [HR (95% CI): 1.338 (1.080–1.658), p = 0.008], were independent indicators of risk for the adverse kidney outcomes. This evidence concerns the gene GSTM1 and chronic kidney disease.