EGFR and lung cancer: State1 cells were found to communicate closely with fibroblasts and M2-type macrophages via the POSTIN–(ITGAV+ITGB5) and MDK–(ITGA6+ITGB1) signaling pathways, respectively; however, State2 cells promoted tumorigenesis by interacting with microenvironmental cells through a different communication mode, such as the HBEGF–EGFR pathway that induces the proliferation and growth of lung cancer cells (34).