In addition, we found that soluble mediators differentially modulated in CCC as compared to CTRL mainly contribute to the enrichment of inflammatory signaling pathways such as: (i) cytokine-cytokine receptor interaction, (ii) IL-17 signaling, (iii) Chagas disease, (iv) Toll-like receptors (TLR), (v) TNF signaling and (vi) chemokine signaling (Figure 3A). Here, TNF is linked to Chagas disease.