Conversely, higher levels of IL-18 (OR [95%CI] = 0.94 [0.90,0.99], P = 1.53E-02, P adjust = 3.14E-01) and HGF (OR [95%CI] = 0.89 [0.79,1.00], P = 4.73E-02, P adjust = 5.82E-01) decreased MS severity with suggestive evidence (Figure 4; Supplementary Tables S7, S8). Here, IL18 is linked to myeloid sarcoma.