MSH6 and metastatic malignant neoplasm in the lymph nodes: In univariate Cox analysis, the p values of the stage (p<0.001), grade (p=0.022), histological (p=0.006), lymph node metastasis (p<0.001) and MSH6 (p=0.008) were significant, but only MSH6 (p=0.005) remained an independent risk factor for predicting adverse outcomes in multivariate Cox regression analysis (Supplementary Table S1).