In the MSH6 high expression group, the enriched GO terms were mainly related to the regulation of mitosis, DNA replication and organism development (Figure 5B); the enriched KEGG pathways were not only associated with the cell cycle and DNA replication and DNA damage repairs related pathways such as homologous recombination, mismatch repair and base excision repair, it also involved multiple cancer-related pathways such as pancreatic cancer, renal cell carcinoma and chronic myeloid leukemia (Figure 5D). The gene discussed is MSH6; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.