Likewise, the expression of NDRG2 (45), PTEN (46), CDKN2C (46), CDKN1A (46), p21 (47, 48), p15 (48, 49), N-cadherin (48), is repressed by MYC, and therefore suppresses tumor suppressing functions, leading to cancer progression (50). Here, CDKN1A is linked to cancer.