Several meta-analyses suggest that susceptibility genes, such as TNF-α polymorphisms (rs769178) (47), the SNPs (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, and rs2201841) of IL-23R (48), and the SNPs (rs27044, rs10050860, rs2287987, rs17482078, rs26653, rs30187, rs27037, rs27980, and rs27582) of endoplasmic reticulum aminopeptidase 1 (49), could influence the susceptibility to ankylosing spondylitis in the total population. The gene discussed is TNF; the disease is ankylosing spondylitis.