Dysregulated inflammasome activation has been implicated in autoimmune disease pathogenesis, and SARS-CoV-2 can activate the inflammasome (nod-like family, pyrin domain-containing 3, or NLRP3), which regulates the secretion of proinflammatory cytokines interleukin 1 beta (IL-1β) and IL-18 (6). The gene discussed is IL1B; the disease is autoimmune disease.