Western blotting and qPCR analysis indicated that reduced METTL3 levels caused up-regulated TCF7L2 expression, whereas overexpression of METTL3 increased TCF7L2 expression (Fig. S8E and F).We further established stable cell lines overexpressing METTL3 in ccRCC cells with stable HIF2α knockdown. Here, TCF7L2 is linked to nonpapillary renal cell carcinoma.