Most ccRCC cases are connected with the inactivation of the cancer inhibitor gene von Hippel–Lindau (VHL) [3], which causes the dysregulation of hypoxia-inducible factors 1 alpha (HIF1α) and 2 alpha (HIF2α) through the ubiquitin-dependent degradation pathway [4]. Here, EPAS1 is linked to nonpapillary renal cell carcinoma.