EPAS1 and nonpapillary renal cell carcinoma: Western blotting and qPCR analysis indicated that reduced METTL3 levels caused up-regulated TCF7L2 expression, whereas overexpression of METTL3 increased TCF7L2 expression (Fig. S8E and F).We further established stable cell lines overexpressing METTL3 in ccRCC cells with stable HIF2α knockdown.