Employing chromatin immunoprecipitations (CHIP), one study has suggested that E3 ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) may play a crucial role in the profound silencing of tumor suppressor genes (TSGs) such as HHIP, IGFBP3, and SFRP1 in hepatoblastoma. The gene discussed is HHIP; the disease is hepatoblastoma.