Among the 92 patients with radiobinding assay data for GAD, IA-2, and insulin autoantibodies, 51 tested positive for two or more islet autoantibodies, and 34 progressed to stage 3 T1D during the follow-up period, with a median time to diagnosis of 3.4 years (Figure 3, Table 4). This evidence concerns the gene GAD1 and type 1 diabetes mellitus.