SOD1 and hepatocellular carcinoma: Diterpenoid, an isolate from T. cordifolia, has been reported to contain chemopreventive potential in diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in rats by decreasing anti-oxidant activities via sodium dismutase (SOD), catalase (CAT), and detoxification enzymes like GSH and GPx, and subsequently increasing the activities of hepatic markers such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), and LDH, and decreasing serum transaminase level, thus confirming its anti-tumor effects [21,85].