While there are no FDA-approved medications for NAFLD/NASH, dietary and lifestyle interventions are the mainstay of treatment, and pharmacological therapy also plays a certain role in the treatment of NASH, including insulin sensitizers, antioxidants, lipotoxicity-based targets, modulation of nuclear transcription factors, gastrointestinal hormones, and cytokines. This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.