They also provided detailed molecular mechanisms of how IFP-MSCs effectively inhibit the arthritis inflammation, including the regulation of inflammatory factor expression, the modulation of inflammatory pathways activation, and the induction of SP degradation through the overexpression of CD10 (Kouroupis et al., 2019; Greif et al., 2020; Kouroupis et al., 2020; Kouroupis et al., 2023). Here, MME is linked to arthritic joint disease.