MME and breast cancer: Moreover, Su et al. proposed that CD10+GPR77+ cancer-associated fibroblasts (CAFs), a type of stromal cell in the tumor microenvironment, contribute to the secretion of interleukin (IL)-6/8 and create a survival niche that not only nurtures the stemness of breast cancer cells but also shields them from the lethal effects of chemotherapy (Su et al., 2018).