Moreover, Su et al. proposed that CD10+GPR77+ cancer-associated fibroblasts (CAFs), a type of stromal cell in the tumor microenvironment, contribute to the secretion of interleukin (IL)-6/8 and create a survival niche that not only nurtures the stemness of breast cancer cells but also shields them from the lethal effects of chemotherapy (Su et al., 2018). The gene discussed is MME; the disease is breast carcinoma.