The Lycium barbarum polysaccharide (LBP) significantly downregulated the expression of N-methyl-D-aspartate receptor 2B subunit (NR2B) and calmodulin kinase II (CaMKII) proteins, reduced serum CORT levels, and enhanced the negative feedback regulation of the HPA axis, thereby ameliorating depressive behaviors in rats with post-traumatic stress disorder (PTSD) (Chu, 2019). The gene discussed is GRIN2B; the disease is post-traumatic stress disorder.