Furthermore, the myelination deficiency of the neurons in the dorsal hippocampal DG and abnormal dendrites in DG IML of TPP2 knockout female mice can be rescued by injection of AAV2/BBB vector harbouring aromatase expression cassette (Figure 12G and H), suggesting that injection of AAV2/BBB can be used to treat TPP2 mutation-induced human intellectual disability and sterile brain inflammation mimicking MS 6, 7. This evidence concerns the gene TPP2 and Intellectual disability.