MS39 (HCC827 cells: DC50 = 5 nM; H3255 cells: DC50 = 3.3 nM) and MS154 (HCC827 cells: DC50 = 11 nM; H3255 cells: DC50 = 25 nM) effectively induced the degradation of mutant EGFR in cancer cells. This evidence concerns the gene EGFR and cancer.