Wen et al. created the initial class of EZH2 degraders, of which the two most potent members, YM181 (compound 88) and YM281 (compound 89) (Figure 17C), exhibited effective antiproliferative activities in DLBCL, as well as in other subtypes of lymphoma cell lines 81. Here, EZH2 is linked to diffuse large B-cell lymphoma.