Wang et al. developed a BET degrader, QCA570 (compound 45) (Figure 10E), that simultaneously caused the BRD2, 3, and 4 degradations in human leukemia cell lines and showed picomolar potency against MV4-11, MOLM-13, and RS4-11 human acute leukemia cell lines 55. The gene discussed is BRD2; the disease is leukemia.