It selectively degraded EED (Dmax = 95%), EZH2 (Dmax = 95%), and SUZ12 (Dmax = 80%), and it was observed that the proliferation of both the EZH2 mutant diffuse large B-cell lymphoma (DLBCL) cell line and the EZH2 wild-type (WT) rhabdoid cancer cell line was effectively suppressed. The gene discussed is EED; the disease is diffuse large B-cell lymphoma.