Based on this novel E3 ligand, they designed a novel JQ-1-based BRD4 degrader, SJ995973 (compound 4) (Figure 4A), with a higher efficiency that showed a highly potent antiproliferative efficacy in human AML MV4-11 (IC50 = 3 pM). The gene discussed is BRD4; the disease is acute myeloid leukemia.