Reduced PPT2-EGFL8/miR-423-5p binding activates hypoxia-induced peroxisome proliferator-activated receptor-β/δ (PPARD)/angiopoietin-like 4 (ANGPTL4) signaling pathway, leading to diabetes-related neovascularization and retinal vessel breakage 62. The gene discussed is ANGPTL4; the disease is diabetes mellitus.