CEACAM5 and colorectal carcinoma: By removing samples with normal CEA measurements from the positives predicted by the metabolic clock classifier, we created a multi-target panel (nine metabolites plus CEA) that improved the PPVs to 68.4% ((64.3%, 72.2%), p=1.3x10-5) for APL, and 21.4% (17.8%-25.9%), p= 1.2x10-10) for CRC.