Our metabolic clock panel results significantly outperformed previous findings, with a much-improved positive predictive value (PPV) for APL (65.5%) and CRC (12.7%) (Table 2) than CologuardTM18 (20.0% for APL and 3.72% for CRC) and Septin 9 methylation tests (9.5% for APL and 2.3% for CRC) 28. Here, SEPTIN9 is linked to colorectal carcinoma.