In the animals fed a cysteine-free diet, PANC-1 tumors derived from the co-implantation with control CAFs (shCtrl or vehicle) showed significantly increased tumor growth relative to tumors co-implantation with CBS-depleted CAFs (shCBS or AOAA treatment), while this phenomenon was significantly abolished by supplementing cysteine in the mouse diet (Figure 5H, Figure S4H). The gene discussed is CBS; the disease is neoplasm.