For example, 1 mm BH treatment spacing has been used to generate immunological responses consistent with antigen trafficking to TDLN in immunogenic MC-38 colon adenocarcinoma 11 and EG.7-OVA lymphomas 12, with 1-2 mm spacing showing efficacy in E0771 and MM3MG-HER2 breast tumors 13. This evidence concerns the gene ERBB2 and breast neoplasm.