PRKDC and serum lipopolysaccharide activity: Intracellular protein analyses using Western blotting similarly showed that MOTS-c expression was restored to near-normal levels after lipopolysaccharide treatment in DNA-PKcsf/f/TieCre CMECs, but not in DNA-PKcsf/f/TieCre cardiomyocytes (Figure 6E-G), suggesting that EC-specific DNA-PKcs deletion stabilized MOTS-c expression in ECs during endotoxemia.