Consistent with the above results, the pharmacological blockade of DNA-PKcs reduced erythrocyte accumulation (Figure S1A), and prevented coagulation activation (Figure S1B-C), ultimately suppressing myocardial injury (Figure S1D-G), sustaining heart function (Table S6) and extending the survival time (Figure S1H) in a murine lipopolysaccharide-induced endotoxemia model. This evidence concerns the gene PRKDC and serum lipopolysaccharide activity.