These results are not surprising, given that the KEGG entry for the “Prion disease” pathway includes many genes known to be involved in drug-induced neuropathologies, including Erk1/2, CREB, Egr1, p38/JNK, GSK-3B, PKA, Fyn, and other genes involved in proteosomal and mitochondrial function [43, 44, 49–51, 56–59]. Here, CREB1 is linked to prion disease.