Interestingly, infusion of a miR-137-specific antagomir into the CeA also reversed these AIE-induced phenotypes: anxiety-like behaviors were attenuated, voluntary ethanol consumption was normalized, the decreased Lsd1 and Lsd1+8a mRNA expression was rescued, the decreased LSD1 binding to the Bdnf IV promoter was restored, the increased H3K9me2 occupancy at the Bdnf IV promoter was normalized, and the decreased expression of Bdnf was rescued. This evidence concerns the gene KDM1A and Anxiety.