TARDBP and amyotrophic lateral sclerosis: Abnormal cleavage, hyperphosphorylation, ubiquitination, and fragmentation are associated with nuclear depletion and extranuclear localization of the TDP-43 protein, which is a major pathological finding in people with ALS and points to the dysfunction of TDP-43 as a critical component of the disease (Buratti and Baralle, 2008; Kabashi et al., 2008; Buratti, 2015; Palomo et al., 2019; Jo et al., 2020).