The plasma concentrations of the pro-inflammatory cytokines significantly increased in the ALS + vehicle group compared with the WT + vehicle group (2.37 ± 0.21-fold increase in TNF-α, and 2.41 ± 0.10-fold increase in IL-6), indicating comparatively high levels of systemic inflammation. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.