Last, phosphorylation of TDP-43 (pTDP-43; Ser409/410) in sciatic nerve homogenates was quantified as the driver of ALS-like disease progression in this transgenic model and as a common histopathologic finding in clinical ALS (Figure 5N) (Neumann et al., 2009; Suk and Rousseaux, 2020; Riva et al., 2022). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.