TARDBP and amyotrophic lateral sclerosis: Although several pathologic signatures contribute to ALS, a consistent hallmark is glutamate-mediated excitotoxicity, which can trigger a cascade of neurodegenerative events that lead to mitochondrial dysfunction, caspase activation, oxidative stress, TDP-43 extranuclear inclusions, neurite degeneration, and motor neuron death (Corona et al., 2007; Boussicault et al., 2020; Obrador et al., 2020).