Levels of proinflammatory cytokines, including interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α), are elevated in the plasma and cerebrospinal fluid (CSF) of people with ALS, reinforcing the role that systemic inflammation may play in the disease mechanism and progression (Tortelli et al., 2020). This evidence concerns the gene IL6 and amyotrophic lateral sclerosis.