IL6 and amyotrophic lateral sclerosis: Elevated levels of IL-6 in the serum and CSF have been reported in people with ALS, positively correlating with the rate of disease progression (Sekizawa et al., 1998; Ono et al., 2001; Moreau et al., 2005; Mizwicki et al., 2012; Wosiski-Kuhn et al., 2019).