Notwithstanding the fact that PD-L1 expression correlates with disease stage and prognosis in some tumoral contexts, among which lung adenocarcinoma, nasopharyngeal carcinoma and non-small cell lung cancer (Nie et al., 2021; Zhou et al., 2023), the relationship between surface PD-L1 and disease parameters remains largely unknown. The gene discussed is CD274; the disease is lung adenocarcinoma.