For other TM4SF members, it was found that the glycosylation of CD63 was found downregulated by the knockdown of RPN2 (which is part of an N-oligosaccharyle transferase complex) in breast cancer, and silencing CD63 suppressed the chemoresistance and aggressiveness of tumor cells (Tominaga et al., 2014). This evidence concerns the gene CD63 and neoplasm.