CD151 has been demonstrated to promote osteosarcoma pulmonary metastasis, and depletion of CD151 in cancer cells significantly suppressed integrin β1, FAK, p-mTOR, and p70s6 levels as well as Akt, p56 and p38 phosphorylation (Wang et al., 2016). The gene discussed is AKT1; the disease is osteosarcoma.