ACE2 and COVID-19: Transgenic mice expressing hACE2 under the control of various promoters, including K18, HFH4, CAG, and human or mouse ACE2 promoters, have been used to determine susceptibility to SARS-CoV-2 infection and could reproduce some clinical manifestations and pathologies of COVID-19 (Bao et al., 2020; Golden et al., 2020; Jiang et al., 2020; Sun et al., 2020; Asaka et al., 2021; Seo et al., 2022).