PIK3CA and cervical cancer: In addition to these findings, several reports have identified driver mutations in cervical cancer, such as PIK3CA (phosphatidylinositide 3-kinases catalytic subunit α), a central protein in the PI3K pathway, KRAS (Kirsten rat sarcoma viral oncogene homolog), and EGFR (epidermal growth factor receptor) (Lin et al., 2019).