(2022] showed that the dosage of NGR1 in mice (30 mg/kg/d) and epithelial cells (4 μM) can reduce the mitochondrial fission in allergic rhinitis, the same dose was chosen by us to explore the effects of NRG1 on the mitochondria of endothelial cells under sepsis. The gene discussed is RTN4R; the disease is allergic rhinitis.