In ≥ 60 controls, 4 CDKAL1 loci showed positive associations (rs7756992, rs9366354, rs10946403, rs4712523; OR = 1.39, 1.34, 1.34 and 1.36, respectively (P < 1 × 10–5 In all)) while 3 other CDKAL1 loci showed negative associations (rs10946415, rs4710944, rs9465895; OR = 0.71, 0.73 and 0.73, respectively (P < 1 × 10–5 In all)) with T2D (Supplementary Table 2, Supplementary Fig. 4). This evidence concerns the gene CDKAL1 and type 2 diabetes mellitus.