CDKAL1 and type 2 diabetes mellitus: In ≥ 65 controls, 3 CDKAL1 loci had more significant associations with T2D (rs7756992, rs4712523, and rs10946403; OR = 1.40, 1.39, 1.38 and P = 2.01 × 10–06, 3.24 × 10–06 and 8.86 × 10–06, respectively) (Supplementary Fig. 5).