Moreover, numerous Ser/Thr kinases (STKs) were either increased (e.g., GRK2, ROCK2, ROCK1, PAK1) or decreased (e.g., BMP2K, TNIK, MYLK, and NRBP1) in expression in the patient samples, suggesting a widespread change in the kinome caused by pathogen infection (Fig. 4A). The gene discussed is GRK2; the disease is infection.