TNF and Hyperglycemia: There is increasing evidence that cytokines (such as TNF-α, IFN-γ) [42], mutations in myelin protein zero (MPZ) [43], Acanthamoeba [44] and long-term hyperglycemia conditions [45, 46] induce Schwann cell death, then disrupt peripheral nerve support and neuropathy, and delay peripheral nerve regeneration [5, 47].