Interestingly, similar to EIF4G2, KIF5B seems to have divergent roles depending on the tumor context; in triple negative metastatic breast cancer cells, KIF5B levels were increased, leading to acquisition of EMT, invasiveness and stem-like phenotype [44, 45], but silencing of KIF5B in epithelial MDCK cells induced EMT, and enhanced invasive and tumorigenic properties [46]. This evidence concerns the gene KIF5B and neoplasm.