Compared with WT colitis mice given Pg (WT (DSS+Pg) group), simultaneous administration of LA (WT (DSS+Pg+LA) group) significantly alleviated the reduction in colon length, weight loss, DAI and HAI (Fig. 7b–g), validating the above experimental findings that gavaging colitis mice with Pg resulted in acute reduction in the levels of the metabolite LA, which in turn aggravated colitis. Here, JUP is linked to colitis.