In orthotopic transplantation or HDI-induced murine HCC model, we observed that DMN-induced cirrhosis increased neutrophils and NETs in the tumors, with or without a decrease of CD8+ T cells (Fig. 3C–G and Additional file 6: S6), which was consistently observed in the subcutaneous implantation model (Fig. 3H–L). Here, CD8A is linked to Cirrhosis.