HTT and Huntington disease: This leads to an abnormally elongated polyglutamine tract within the mutant huntingtin protein, which elicits cytotoxicity and neural cell death through both gain-of-function and loss-of-function mechanisms, ultimately leading to the characteristic clinical manifestations of HD.121 In terms of protein translation interventions for Huntington’s disease, potential strategies include targeting Huntington’s DNA and RNA as well as promoting protein clearance.121–123