MAPT and Alzheimer disease: These compounds were able to rescue deficits and provide neuroprotection in vitro as well as in mouse models of prion disease and tauopathy.99 As the most prevalent neurodegenerative disorder, AD is characterized aberrant accumulation of misfolded proteins in the endoplasmic reticulum (ER).116 In AD, aggregates are composed of the amyloid-β (Aβ) peptide and tau protein, which form extracellular amyloid plaques and intracellular neurofibrillary tangles (NFT), respectively.