EIF4E and neoplasm: Overexpressing eIF3f inhibits cell proliferation and induces apoptosis.233 In lymphoma models, inhibiting eIF4A and translation can restore chemosensitivity to doxorubicin.234 eIF4F inhibition may also decrease PD-L1 expression and stimulate anti-tumor immunity in melanoma.235 eIF4A inhibition with silvestrol suppresses Sin1 translation and attenuates invasion in colon carcinoma.236