Furthermore, Gastrodin improved learning and memory while ameliorating oxidative stress in the hippocampi of Tg2576 mice overexpressing the Swedish mutation of the amyloid precursor protein, suggesting it may be a potential candidate of AD treatment.119 Genetic or pharmacological inhibition of eIF2α phosphorylation can restore memory and prevent neurodegeneration.120 HD is a progressive and fatal neurodegenerative disorder. This evidence concerns the gene EIF2A and Alzheimer disease.