Immunohistochemistry result for breast mass testified strongly positive staining for estrogen receptor (ER) and progesterone receptor (PR) in most tumor cells (3+), 2 + staining for human epithelial receptor 2 (HER-2), 3 + staining for androgen receptor (AR) and 10% positive Ki67 in tumor cells. The gene discussed is ESR1; the disease is neoplasm.